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1 2 3 Br Substitution occurs with a mixture of retention and inversion at a stereocenter H 2O 1 2 HO 1 2 3 OH retention inversion + H 3O Br The rate of the reaction is ONLY sensitive to the concentration of the substrate ( and not the nucleophile) Rate [ 12 3 4 Br] 2 3 4 H 2O ] 1 2 3. Intelligent races who are not EARTH HUMANS.